Drugs

Atropine Sulfate 0,25mg/ml - 0,50mg/ml - 1mg/ml Injectable Ampoule

Atropine Sulfate (Injectable Ampoule)

Presentation

 

VolumeDosage
 1ml0,25mg 
 1ml0,50mg
 1ml1mg

 

Pharmacodynamics
Antispasmodic, Anticholinergic, Premedication in anaesthesia, Antiarythmic
(A: Digestive system and metabolism; C: Cardiovascular system)

 

Antidote (V: Miscellaneous) (Atropine Sulfate 1mg/ml)

 

Pharmacokinetics

  • plasma half-life is from 2 to 2 hours 30. Metabolism occurs through hydrolysis and glucuroconjugation.
  • Ecretion path is through kidney. 1/3 unchanded and 2/3 glucuroconjugated form.
  • Atropine crosses the placenta barrier and is exreted in the maternal milk.


Therapeutic Indications of atropine sulfate

  • Preanesthesia : protection against vagal manifestations (bradycardia following induction ).
  • Auriculoventricular block (AVB) or atrioventricular Block.
  • Infarctus: prevention and treatment of auriculoventricular blocks and sinusal bradycardias.
  • Symptomatic treatment of acute painful episodes of functional disorders related to digestive tract and bile ducts.
  • Symptomatic treatment of spasmodic and painful episodes of urinary tract.

    Dose 1 mg/1 ml : specific additional indication
  • Specific antidote in acute intoxication with anticholinesterasic (organo-phosphorated insecticides and carbamates) or with parasympathomimetic or cholinomimetic drugs.

 

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