Drugs

Magnesium sulfate 15% (0,15 g/ml) Injectable Ampoule

Magnesium sulfate (Injectable Ampoule)

Presentation

   

Volume Dosage 
 10ml 1,5g
 20ml 3g

 

 

Pharmacodynamics
Magnesium salts solution (B: Hematopoietic stem cells blood and lymphoid organs)

 

Physiologically :
Magnesium is a cation primarily intracellular. It decreases neuronal excitability and neuromuscular transmission and is involved in several enzymatic reactions. Constitutional element, half of magnesium builds bone mass.

 

Clinically :
Serum magnesemia :
- ranging from 12 to 17 mg/l (1 to 1.4 mEq/l or 0.5 to 0.7 mmol/l) indicates moderate magnesium deficiency,
- under 12 mg/l (1 mEq/l or 0.5 mmol/l) indicates severe magnesium deficiency.

 

Magnesium deficiency may be:

  • Primary by congenital abnormality of metabolism (chronic congenital hypomagnesemia).
  • Secondary by:
    • inadequate nutritional supplements (severe denutrition, alcoholism, parenteral nutrition
      exclusively),
    • digestive malabsorption (chronic diarrhoea, digestive fistulas, hypoparathyroidy),
    • excessive increase of renal losses (tubulopathies, severe polyurias, diuretics abuse, chronic pyelonephritis, primary hyperaldosteronism, treatment with cisplatin).

 

Pharmacokinetics
Urinary excretion mainly.

 

Therapeutic Indications of magnesium sulfate 

  • Curative treatment of torsades de pointe (TdP)
  • Treatment of acute hypokalaemia associated with hypomagnesemia
  • Magnesium supplement during electrolyte rebalance
  • Magnesium supplement in parenteral nutrition
  • Preventive and curative treatment of eclampsia crisis

 

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