Drugs

Procaine hydrochloride 1% - 2% Injectable Ampoule

Procaine hydrochloride (Injectable Ampoule)

Presentation

 

Volume Concentration 
 2 ml 1 %
 5 ml  1 %
 2 ml 2 %
 5 ml 2 %

 

 

 

 

 

 

 

 

 

Pharmacodynamics
Ester-group local anaesthesic (N: central nervous system)

 

Pharmacokinetics

  • Procaine coefficient of variation is 0.02 and Acid Dissociation Constant (pKa) 8.9.
  • After injection, the diffusion is extremely wide and rapid, providing an optimal effect within 1 to 2 minutes during 20 to 40 minutes.
  • Procaine is acetylated into liver then hydrolized in plasma by a pseudocholinesterase in acid paraaminobenzoic and diethylaminoethanol.
  • The plasmatic proteins binding accounts for about 6 %.
  • 80% of acid para-aminobenzoique whether combined or not are excreted in urine, 20% metabolized in liver.
  • 30% of diethylaminoethanol are excreted in urine, the remainder being metabolized in liver.
  • Elimination half-life lasts a few minutes.
  • Procaine crosses the placenta.

 

Therapeutic Indications of procaine hydrochloride 
Local infiltration anaesthesia and conduction anaesthesia (plexic and troncular blocks)

 

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