Procaine hydrochloride 1% – 2%
Injectable Ampoule

THERAPEUTIC INDICATIONS

• Local infiltration anaesthesia and conduction anaesthesia (plexic and troncular blocks)

PHARMACEUTICAL FORM

Procaine hydrochloride is available in glass ampoule with an OPC (one point cut) opening system.

PHARMACO-THERAPEUTIC CLASS

Ester-group local anaesthesic (N: central nervous system)

PHARMACOKINETICS

• Procaine coefficient of variation is 0.02 and Acid Dissociation Constant (pKa) 8.9.
• After injection, the diffusion is extremely wide and rapid, providing an optimal effect within 1 to 2 minutes during 20 to 40 minutes.
• Procaine is acetylated into liver then hydrolized in plasma by a pseudocholinesterase in acid paraaminobenzoic and diethylaminoethanol.
• The plasmatic proteins binding accounts for about 6 %.
• 80% of acid para-aminobenzoique whether combined or not are excreted in urine, 20% metabolized in liver.
• 30% of diethylaminoethanol are excreted in urine, the remainder being metabolized in liver.
• Elimination half-life lasts a few minutes.
• Procaine crosses the placenta.